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KMID : 0380020030180010019
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Korean Journal of Biotechnology and Bioengineering
2003 Volume.18 No. 1 p.19 ~ p.24
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Screening of the Immuno-stimulatory Activity of the Marine Alga Chlorella capsulata
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Lee Hyun-Soo
Lee Seo-Ho
Mun Hyoung-Chul
Lee Hyeon-Yong
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Abstract
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A purified substance was separated from marine alga, Chlorella capsulate. Immuno-stimulatory activity was measured by observing the growth of human immune T and B cells. The growth of human T and B cells was enhanced by up to about 1.4 times by adding the fraction from C. capsulata, compared with commercially available CGF extracts from the fresh water alga, C. vulgaris. The secretion of TNF-a and IL-6 was also enhanced up to about 1.5 times by adding the separated fraction. Adding 0.4 g/L of the extract increased the production of nitric oxide from macrophages by 1.6 fold. 50% of the AGS cell growth was inhibited by adding 0.4 g/L of the water extracted sample.
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KEYWORD
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Chlorella capsulata, human T and B cells, macrophage, immuno-stimulatory activity
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